Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27493979 | 0.86 | ADRB1 (0.40) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL7347467 | 0.83 | CPN1 (0.47) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL7461910 | 0.83 | CPN1 (0.47) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL5796124 | 0.82 | APP (0.47) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL7336123 | 0.81 | CPN1 (0.43) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL7210714 | 0.80 | CPN1 (0.42) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL27494783 | 0.79 | ADRB2 (0.40) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL7461918 | 0.77 | CPN1 (0.40) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL28741995 | 0.77 | CPN1 (0.40) | CPN1CPB2ADRB2ADRB1ADRB3 | |
| SCHEMBL24851748 | 0.76 | KMT2A (0.52) | KMT2AMEN1ALDH1A1MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470899-B | The 4 isoquinolinol compounds as HIF hydroxylase inhibitors | 菲布罗根有限公司 | 2017-12-26 | — | — | CN | disclosed |
| CN-104470899-A | 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-03-25 | — | — | CN | disclosed |