Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 3/20 | 0.44 |
| ▸ | XIAP | P98170 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836117 | 0.75 | HSD17B10 (0.44) | ALDH1A1MAPTL3MBTL1ENPP3ALPL | |
| SCHEMBL27564845 | 0.72 | TSHR (0.44) | TDP1ALDH1A1MAPTL3MBTL1ALOX15 | |
| SCHEMBL3506128 | 0.72 | TSHR (0.52) | TDP1ALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL27854323 | 0.71 | TSHR (0.43) | TDP1ALDH1A1MAPTL3MBTL1ALOX15 | |
| SCHEMBL23564635 | 0.70 | ENPP3 (0.47) | TDP1ALDH1A1MAPTL3MBTL1ENPP3 | |
| SCHEMBL13879706 | 0.68 | HDAC3 (0.57) | GAARAB9A | |
| SCHEMBL27464997 | 0.68 | TSHR (0.47) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL31055014 | 0.68 | RAB9A (0.73) | ALDH1A1POLBKMT2AGAARAB9A | |
| SCHEMBL4417365 | 0.67 | LMNA (0.48) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL16797417 | 0.65 | LMNA (0.50) | TDP1ALDH1A1MAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102369196-B | Azetidines as histamine h3 receptor antagonists | EVOTEC NEUROSCIENCES GMBH | 2015-05-20 | — | — | CN | disclosed |