Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | SCN2B | O60939 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800486 | 0.90 | ALDH1A1 (0.35) | ALDH1A1RBP4SMN1; SMN2MRGPRX1SCN9A | |
| SCHEMBL2801665 | 0.88 | RBP4 (0.46) | ALDH1A1RBP4SMN1; SMN2KRASHPGDS | |
| SCHEMBL2800917 | 0.87 | SMN1; SMN2 (0.34) | ALDH1A1SMN1; SMN2SCN9ASCN2BSCN1A | |
| SCHEMBL2800359 | 0.87 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2MRGPRX1SCN9A | |
| SCHEMBL2800835 | 0.86 | MCHR2 (0.34) | ALDH1A1SMN1; SMN2MRGPRX1 | |
| SCHEMBL2800975 | 0.85 | RBP4 (0.37) | ALDH1A1RBP4SMN1; SMN2KRASHPGDS | |
| SCHEMBL2800950 | 0.83 | RBP4 (0.39) | RBP4KRASHPGDSHPGDHSD11B1 | |
| SCHEMBL2801254 | 0.80 | ADRA1A (0.36) | ALDH1A1RBP4KRASHPGDS | |
| SCHEMBL2801267 | 0.80 | RBP4 (0.51) | ALDH1A1RBP4KRASHPGDSHPGD | |
| SCHEMBL2801429 | 0.80 | ALDH1A1 (0.32) | ALDH1A1MRGPRX1HPGDSCN9ASCN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206714-B1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2206714-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | ALDH1A1 243/4885RBP4 92/4885SMN1; SMN2 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.