SCHEMBL28017016

SCHEMBL28017016

Cc1ccc(S(=O)(=O)n2c(-c3ccc(F)cc3)cc3ccccc32)cc1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.63
CA9 Q16790 3/20 0.63
CA2 P00918 1/20 0.63
NOD1 Q9Y239 4/20 0.55
NOD2 Q9HC29 3/20 0.55
ALDH3A1 P30838 2/20 0.52
CREBBP Q92793 1/20 0.48
ALOX5 P09917 1/20 0.48
ACLY P53396 5/20 0.47
GAA P10253 2/20 0.46
CXCL8 P10145 1/20 0.46
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
LMNA P02545 2/20 0.44
THRB P10828 1/20 0.44
HPGD P15428 1/20 0.43
HTT P42858 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28414154 0.93 CA12 (0.71) CA12CA9CA2NOD1NOD2
SCHEMBL28017014 0.89 CA12 (0.69) CA12CA9CA2NOD1NOD2
SCHEMBL28017013 0.87 CA12 (0.63) CA12CA9CA2NOD1NOD2
SCHEMBL14953618 0.86 ACLY (0.61) CA12CA9CA2NOD1NOD2
SCHEMBL28532284 0.86 CA9 (0.61) CA12CA9CA2NOD1NOD2
SCHEMBL28523374 0.85 CA12 (0.60) CA12CA9CA2NOD1NOD2
SCHEMBL28016374 0.84 CA12 (0.62) CA12CA9CA2NOD1NOD2
SCHEMBL4794912 0.82 NOD1 (0.63) CA12CA9CA2NOD1NOD2
SCHEMBL28205246 0.82 NOD1 (0.59) CA12CA9CA2NOD1NOD2
SCHEMBL28529811 0.80 CA2 (0.56) CA12CA9CA2NOD1NOD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104592086-A Method for preparing indole compound through copper salt catalysis UNIV TAIZHOU 2015-05-06 CN claimed
CN-112358432-B Synthetic method of indole derivatives 天津大学 2022-06-10 CN disclosed
CN-107118145-B Method for cyclizing and synthesizing indole under co-catalysis of palladium-organic nitrite 中国科学技术大学 2020-05-05 CN disclosed
CN-104592086-B A kind of method that Benzazole compounds are prepared by mantoquita catalysis 台州学院 2017-06-06 CN disclosed
CN-104592086-A Method for preparing indole compound through copper salt catalysis UNIV TAIZHOU 2015-05-06 CN disclosed