Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044708 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL3599059 | 0.77 | LOX (0.35) | ALOX5APFEN1IDH1LMNAPOLB | |
| SCHEMBL28686868 | 0.77 | GRM4 (0.35) | ALOX5APFEN1IDH1LMNAPOLB | |
| SCHEMBL1750195 | 0.77 | PARP1 (0.38) | ALOX5APFEN1IDH1LMNAPOLB | |
| SCHEMBL3599060 | 0.75 | ENPP2 (0.35) | IDH1LMNAPOLBLOX | |
| SCHEMBL28938658 | 0.75 | ROCK1 (0.45) | ALOX5APLMNAPOLB | |
| SCHEMBL2018052 | 0.75 | IDH1 (0.38) | IDH1LMNAPOLBLOXPTGS1 | |
| SCHEMBL27841654 | 0.75 | HDAC8 (0.33) | IDH1LMNAPOLBLOX | |
| SCHEMBL31475459 | 0.75 | MALT1 (0.40) | IDH1LMNAPOLBMAPK1PTGS2 | |
| SCHEMBL12417898 | 0.71 | TGFBR1 (0.37) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104940202-B | Inhibitors of influenza viruses replication | 沃泰克斯药物股份有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-104940202-A | Inhibitors of influenza viruses replication | VERTEX PHARMA | 2015-09-30 | — | — | CN | disclosed |
| CN-104922128-A | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA | 2015-09-23 | — | — | CN | disclosed |
| CN-102458408-B | Inhibitors of influenza virus replication | VERTEX PHARMA | 2015-06-03 | — | — | CN | disclosed |