Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23597414 | 0.88 | PKM (0.61) | PKMMAPTLMNAHTTALDH1A1 | |
| SCHEMBL2702167 | 0.86 | PKM (0.82) | PKMMAPTLMNAHTTNPSR1 | |
| SCHEMBL12964577 | 0.84 | ALDH1A1 (0.63) | PKMMAPTLMNAHTTALDH1A1 | |
| SCHEMBL2704796 | 0.84 | LMNA (0.66) | PKMMAPTLMNAHTTNPSR1 | |
| SCHEMBL12964649 | 0.83 | PKM (0.68) | PKMMAPTLMNAHTTNPSR1 | |
| SCHEMBL2702669 | 0.79 | ALPL (0.61) | PKMMAPTLMNAHTTNPSR1 | |
| SCHEMBL28023297 | 0.79 | LMNA (0.66) | PKMMAPTLMNAHTTNAMPT | |
| SCHEMBL28023890 | 0.79 | LMNA (0.81) | PKMMAPTLMNAHTTNAMPT | |
| SCHEMBL2701108 | 0.78 | PKM (0.70) | PKMMAPTLMNAHTTNPSR1 | |
| SCHEMBL28023893 | 0.78 | NAMPT (0.61) | PKMMAPTLMNAHTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104817498-A | Therapeutic compounds and compositions | AGIOS PHARMACEUTICALS INC | 2015-08-05 | — | — | CN | disclosed |