Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822639 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAPTCYP2C9LMNA | |
| SCHEMBL28834474 | 0.80 | ACACB (0.46) | ALDH1A1KMT2AMAPTGAAL3MBTL1 | |
| SCHEMBL15187965 | 0.76 | RORC (0.56) | BRD4RORCNR1H2NR1H3FPR2 | |
| SCHEMBL15571861 | 0.75 | MAPT (0.43) | BRD4RORCNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28339045 | 0.74 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL25269763 | 0.74 | BRD4 (0.43) | BRD4RORCNPC1RECQLRAB9A | |
| SCHEMBL28803045 | 0.73 | RIPK1 (0.39) | BRD4MEN1KMT2A | |
| SCHEMBL21382139 | 0.71 | RORC (0.39) | RORC | |
| SCHEMBL28685326 | 0.71 | ALDH1A1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL28876542 | 0.70 | SSTR4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812753-A | Substituted pyridopyrazines as syk inhibitors | HUTCHISON MEDIPHARMA LTD | 2015-07-29 | — | — | CN | disclosed |