Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28025218 | 0.78 | GLA (0.41) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL19596858 | 0.74 | — | — | |
| SCHEMBL28025226 | 0.74 | ALDH1A1 (0.38) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL28025233 | 0.73 | HDAC4 (0.39) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL27448958 | 0.68 | ALDH1A1 (0.49) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL27832676 | 0.68 | ALDH1A1 (0.49) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL27813991 | 0.68 | ALDH1A1 (0.45) | GLAALDH1A1F2HPGDLMNA | |
| SCHEMBL2010436 | 0.67 | LMNA (0.59) | GLAALDH1A1LMNACYP3A4POLB | |
| SCHEMBL7586397 | 0.67 | LMNA (0.50) | LMNACYP3A4POLBMAPTPKM | |
| SCHEMBL27972799 | 0.67 | LMNA (0.47) | GLAALDH1A1F2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |