Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22150604 | 0.74 | PIK3CA (0.49) | PRKDCPIK3CAPIK3CBALDH1A1MEN1 | |
| SCHEMBL3833537 | 0.74 | LMNA (0.48) | PRKDCAPAF1CDC25BCASP3SENP8 | |
| SCHEMBL942469 | 0.69 | PIK3CB (0.51) | PRKDCPIK3CAPIK3CBGAAJAK3 | |
| SCHEMBL28826859 | 0.68 | PIK3CD (0.53) | PRKDCPIK3CAPIK3CBHSD17B10ALDH1A1 | |
| SCHEMBL30602734 | 0.68 | APAF1 (0.50) | PRKDCAPAF1CDC25BCASP3SENP8 | |
| SCHEMBL29778435 | 0.67 | PIK3CD (0.59) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL444108 | 0.67 | GHSR (0.52) | PRKDCPIK3CAPIK3CBHSD17B10TSHR | |
| SCHEMBL4032846 | 0.67 | MAPT (0.47) | PRKDCAPAF1CDC25BCASP3SENP8 | |
| SCHEMBL15987537 | 0.66 | SIGMAR1 (0.56) | HSD17B10ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19051444 | 0.65 | APAF1 (1.00) | PRKDCAPAF1CDC25BCASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |