SCHEMBL28024917

SCHEMBL28024917

CC(C)(C)OC(=O)N(c1cc[c]cc1)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MT-CO2 P00403 1/20 0.32
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
CA14 Q9ULX7 1/20 0.31
PAX8 Q06710 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5559017 0.83 MEN1 (0.39) LMNAPOLBPAX8
SCHEMBL28310488 0.78 PAX8 (0.46) MT-CO2LMNAPAX8
SCHEMBL9899757 0.73 PDK1 (0.42)
SCHEMBL2648822 0.72 NFKB1 (0.32) MT-CO2
SCHEMBL9900418 0.70 LOXL2 (0.40)
SCHEMBL1847986 0.69 MEN1 (0.39) LMNAPOLBPAX8
SCHEMBL26185952 0.68 CTSL (0.43)
SCHEMBL3763750 0.67 MAPT (0.38) MT-CO2POLB
SCHEMBL543053 0.66 CA12 (0.49) CA14
SCHEMBL6250057 0.66 HSD17B10 (0.43) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104803916-A Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) JANSSEN PHARMACEUTICA NV 2015-07-29 CN claimed
CN-104803916-B Hete rocyclic derivatives as SARM (SARMS) 詹森药业有限公司 2017-08-11 CN disclosed
CN-104803916-A Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) JANSSEN PHARMACEUTICA NV 2015-07-29 CN disclosed