Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15570742 | 0.76 | MAPT (1.00) | MAPTKDM4ETP53ALDH1A1MEN1 | |
| SCHEMBL28026890 | 0.76 | EEF2K (0.56) | MAPTKDM4EALDH1A1MEN1ALOX15 | |
| SCHEMBL28026886 | 0.75 | CUL4A (0.51) | MAPTKDM4ETP53ALDH1A1MEN1 | |
| SCHEMBL28027503 | 0.73 | CUL4A (0.59) | CUL4A | |
| SCHEMBL28027514 | 0.73 | CUL4A (0.54) | MAPTKDM4ETP53ALDH1A1MEN1 | |
| SCHEMBL28027509 | 0.69 | CUL4A (0.55) | MAPTKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL28026889 | 0.68 | CUL4A (0.54) | MAPTKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL28026887 | 0.68 | KMT2A (0.40) | MAPTKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL28026888 | 0.68 | KMT2A (0.43) | MAPTKDM4ETP53ALDH1A1MEN1 | |
| SCHEMBL28027511 | 0.67 | ALDH1A1 (0.58) | MAPTKDM4ETP53ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | claimed |
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | disclosed |