Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16097475 | 0.77 | FPR2 (0.43) | CHRNB2CHRNA7CHRNA4MGLLKMT2A | |
| SCHEMBL16097844 | 0.73 | MGLL (0.44) | CHRNB2CHRNA7CHRNA4MGLLKMT2A | |
| SCHEMBL19253606 | 0.73 | PDE4A (0.44) | MGLLKMT2APOLBHPGDALDH1A1 | |
| SCHEMBL14037470 | 0.66 | NPC1 (0.58) | KMT2APOLBALDH1A1LMNAMEN1 | |
| SCHEMBL28876806 | 0.66 | MEN1 (0.49) | KMT2AHSD11B1HPGDALDH1A1MEN1 | |
| SCHEMBL21590312 | 0.65 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4MGLLKMT2A | |
| SCHEMBL16099787 | 0.65 | MGLL (0.44) | CHRNB2CHRNA7CHRNA4MGLLKMT2A | |
| SCHEMBL30620187 | 0.64 | POLB (0.47) | MGLLPOLBHSD11B1HPGDMAPT | |
| SCHEMBL28793789 | 0.63 | ENO1 (0.33) | ENO1 | |
| SCHEMBL2134992 | 0.62 | NPC1 (0.54) | KMT2APOLBHSD11B1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189497-B | N- (2- cyano heterocycle) Pyrazolopyridine ketone as JANUS kinase inhibitor | 默沙东公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-105189508-B | Naphthenic base nitrile Pyrazolopyridine ketone as JANUS kinase inhibitor | 默沙东公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105189508-A | Cycloalkyl nitrile pyrazolo pyridones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |
| CN-105189497-A | N-(2-cyano heterocyclyl)pyrazolo pyridones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |
| CN-105189498-A | Geminally substituted cyanoethylpyrazolopyridinones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |