Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29529148 | 0.88 | KDM4E (0.54) | KDM4CKDM4ELMNACCR1CCR5 | |
| SCHEMBL439769 | 0.88 | KDM4E (0.54) | KDM4CKDM4ELMNACCR1CCR5 | |
| SCHEMBL27768754 | 0.86 | KDM4E (0.52) | KDM4CKDM4ELMNACCR1CCR5 | |
| Pyridine SCHEMBL28181012 | 0.81 | KDM4C (0.49) | KDM4CKDM4ELMNACCR1CCR5 | |
| SCHEMBL18204056 | 0.76 | KDM4E (0.64) | KDM4CKDM4ELMNACCR1CCR5 | |
| SCHEMBL17850816 | 0.76 | — | — | |
| Quinoline SCHEMBL28115235 | 0.75 | ALDH1A1 (0.55) | KDM4CKDM4ELMNACCR1CCR5 | |
| SCHEMBL5709792 | 0.75 | NOTUM (0.52) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL29664837 | 0.75 | NOTUM (0.52) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL1130221 | 0.74 | FKBP5 (0.59) | FKBP5KDM4ELMNACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870446-A | Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2015-08-26 | — | — | CN | disclosed |