SCHEMBL28030160

SCHEMBL28030160

OC1(F)Cc2ccccc2OC1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.37
MAOB P27338 9/20 0.36
MAOA P21397 7/20 0.36
AOC2 O75106 5/20 0.36
DAO P14920 1/20 0.36
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
ADORA3 P0DMS8 2/20 0.31
HTR2A P28223 1/20 0.31
HRH1 P35367 1/20 0.31
KDM4E B2RXH2 1/20 0.31
AR P10275 1/20 0.31
CYP19A1 P11511 1/20 0.31
HSD17B10 Q99714 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
NPC1 O15118 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30
MAPK1 P28482 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23699018 0.67 MAOB (0.37) NISCHMAOBMAOAAOC2DAO
SCHEMBL19744390 0.65 MAOB (0.45) NISCHMAOBMAOAAOC2DAO
SCHEMBL3122824 0.65 MAOA (0.39) NISCHMAOBMAOATSHRHTR2A
SCHEMBL27937705 0.64 MAOA (0.36) NISCHMAOBMAOAAOC2DAO
SCHEMBL6449692 0.63 LMNA (0.31)
SCHEMBL27735931 0.63 MAOA (0.44) NISCHMAOBMAOAAOC2DAO
SCHEMBL31069756 0.63 MAOB (0.37) NISCHMAOBMAOATSHRHTR2A
SCHEMBL25744874 0.63 NISCH (0.35) NISCHMAOBMAOATSHRHRH3
SCHEMBL19149282 0.62 HTR1A (0.40) NISCH
SCHEMBL29935960 0.62 MAOB (0.42) NISCHMAOBMAOAAOC2DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102770413-B 5-amino-4-hydroxy-pentanoylamides JANSSEN R&D IRELAND (IE) 2015-08-26 CN disclosed