Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27875653 | 0.87 | AAK1 (0.38) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL27894672 | 0.87 | AAK1 (0.38) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL27613183 | 0.85 | MMP8 (0.41) | CTSKCTSSL3MBTL1LTA4HCYP2D6 | |
| SCHEMBL9832084 | 0.85 | ALDH1A1 (0.41) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL4937584 | 0.84 | DPP4 (0.42) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL27564999 | 0.84 | DPP4 (0.42) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL27665873 | 0.84 | DPP4 (0.42) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL28837744 | 0.83 | DPP4 (0.41) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL28261977 | 0.83 | ATM (0.44) | CTSKAAK1CTSSCYP1A2ALDH1A1 | |
| SCHEMBL28040274 | 0.82 | ITGA4 (0.38) | CTSKAAK1CTSSALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017181-A | Carfilzomib key intermediate and preparation method of its derivative | UNIV NANJING NORMAL | 2015-11-04 | — | — | CN | disclosed |