Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27727248 | 0.77 | MAOA (0.33) | MEN1KMT2ANPSR1 | |
| SCHEMBL20658953 | 0.73 | SMN1; SMN2 (0.31) | NPSR1 | |
| SCHEMBL28023706 | 0.73 | MAPT (0.30) | NPSR1 | |
| SCHEMBL28024161 | 0.73 | MAPT (0.30) | NPSR1 | |
| SCHEMBL27945472 | 0.73 | MAPT (0.30) | NPSR1 | |
| SCHEMBL28031694 | 0.72 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL28031660 | 0.69 | ALDH1A1 (0.33) | — | |
| SCHEMBL29349092 | 0.67 | — | — | |
| SCHEMBL28032265 | 0.67 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL28023719 | 0.66 | FADS1 (0.38) | MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837490-B | Pyrimido [4, 5-b ] quinoline-4, 5(3H, 10H) -diones as nonsense mutation suppressors | 诺华股份有限公司 | 2017-10-03 | — | — | CN | claimed |
| CN-104837490-A | Pyrimido [4,5-b ] quinoline-4, 5(3H,10H) -diones as nonsense mutation suppressors | NOVARTIS AG | 2015-08-12 | — | — | CN | claimed |
| CN-107569487-A | Pyrimido [4,5 b] quinoline 4,5 (3H, 10H) diketone as nonsense mutation repressor | 诺华股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104837490-B | Pyrimido [4, 5-b ] quinoline-4, 5(3H, 10H) -diones as nonsense mutation suppressors | 诺华股份有限公司 | 2017-10-03 | — | — | CN | disclosed |
| CN-104837490-A | Pyrimido [4,5-b ] quinoline-4, 5(3H,10H) -diones as nonsense mutation suppressors | NOVARTIS AG | 2015-08-12 | — | — | CN | disclosed |