Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.63 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.63 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.63 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.63 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.63 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538397 | 0.98 | ABCC4 (0.67) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL9251496 | 0.94 | ABCC4 (0.74) | LMNAGAATSHRABCC4PTGS1 | |
| Methyl Alcohol SCHEMBL7855784 | 0.94 | ABCC4 (0.62) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL3417462 | 0.91 | GRIN2D (0.59) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL7030142 | 0.90 | ACMSD (0.58) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL23296113 | 0.89 | GRIN2D (0.57) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL28373247 | 0.89 | GRIN2D (0.54) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL5269627 | 0.89 | GRIN2D (0.57) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL4213065 | 0.89 | SHMT1 (0.62) | LMNAGAATSHRABCC4PTGS1 | |
| SCHEMBL3936298 | 0.89 | PRKCI (0.64) | LMNAGAATSHRABCC4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026403-A | Tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | disclosed |