SCHEMBL538397

SCHEMBL538397

O=C(O)Cc1cccc(-c2ccccc2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCC4 O15439 1/20 0.67
LMNA P02545 1/20 0.67
GAA P10253 1/20 0.67
TSHR P16473 1/20 0.67
PTGS1 P23219 1/20 0.67
HTT P42858 1/20 0.67
AKR1B1 P15121 1/20 0.64
GRIN2D O15399 1/20 0.61
GRIN3B O60391 1/20 0.61
GRIN1 Q05586 1/20 0.61
GRIN2A Q12879 1/20 0.61
GRIN2B Q13224 1/20 0.61
GRIN2C Q14957 1/20 0.61
GRIN3A Q8TCU5 1/20 0.61
ENPP2 Q13822 2/20 0.59
PTGS2 P35354 1/20 0.56
NR1H4 Q96RI1 1/20 0.55
PLA2G10 O15496 1/20 0.55
PLA2G2A P14555 1/20 0.55
AOC3 Q16853 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28032595 0.98 LMNA (0.63) ABCC4LMNAGAATSHRPTGS1
Methyl Alcohol SCHEMBL7855784 0.96 ABCC4 (0.62) ABCC4LMNAGAATSHRPTGS1
SCHEMBL9251496 0.92 ABCC4 (0.74) ABCC4LMNAGAATSHRPTGS1
SCHEMBL27604987 0.89 LMNA (0.68) ABCC4LMNAGAATSHRPTGS1
SCHEMBL3417462 0.89 GRIN2D (0.59) ABCC4LMNAGAATSHRPTGS1
SCHEMBL7030142 0.88 ACMSD (0.58) ABCC4LMNAGAATSHRPTGS1
SCHEMBL17187933 0.88 PLA2G10 (0.60) ABCC4LMNAGAATSHRPTGS1
SCHEMBL3437800 0.88 AOC3 (0.53) ABCC4LMNAGAATSHRPTGS1
SCHEMBL23296113 0.87 GRIN2D (0.57) ABCC4LMNAGAATSHRPTGS1
SCHEMBL3936298 0.87 PRKCI (0.64) ABCC4LMNAGAATSHRPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150025020-A1 SELF-PRESERVED OIL DISPERSIONS COMPRISING BORIC ACID SANTEN SAS (FR) 2015-01-22 US claimed
EP-2816998-A1 SELF-PRESERVED OIL DISPERSIONS COMPRISING BORIC Santen SAS (FR) 2014-12-31 EP claimed
WO-2013124415-A1 SELF-PRESERVED OIL DISPERSIONS COMPRISING BORIC NOVAGALI PHARMA SA (FR) 2013-08-29 WO claimed
EP-2630952-A1 Self-preserved oil dispersions comprising boric acid Novagali Pharma S.A. (FR) 2013-08-28 EP claimed
US-7034187-B2 Poly(aralkyl ketone)s and methods of preparing the same AGENCY FOR SCIENCE, TECHNOLOGY, AND RESEARCH (SG) 2006-04-25 US claimed
US-20050272905-A1 NOVEL POLY(ARALKYL KETONE)S AND METHODS OF PREPARING THE SAME AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH 2005-12-08 US claimed
US-20020032174-A1 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade PHARMACIA CORPORATION 2002-03-14 US claimed
JP-1249720-A None JP disclosed
EP-4727537-A2 SIGLEC LIGANDS, CONJUGATES, AND METHODS OF USE THEREOF Adaxion Therapeutics, Inc. (US) 2026-04-22 EP disclosed
WO-2025235527-A1 CRYSTALLINE FORMS OF A PPAR ALPHA ANTAGONIST TEMPEST THERAPEUTICS, INC. (US) 2025-11-13 WO disclosed
US-12378224-B2 Heteroaryl compounds and their use as Mer inhibitors DONG-A SOCIO HOLDINGS CO., LTD. (KR) 2025-08-05 US disclosed
US-20250213560-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS HAVING PHENYL GROUP AND USES THEREOF BNH RESEARCH CO., LTD. (KR) 2025-07-03 US disclosed
US-20250064941-A1 SIGLEC LIGANDS, CONJUGATES, AND METHODS OF USE THEREOF ADAXION THERAPEUTICS, INC. 2025-02-27 US disclosed
EP-0535034-A1 PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1993-04-07 EP disclosed
CN-1058208-A PHARMACEUTICAL COMPOUNDS WELLCOME FOUND (GB) 1992-01-29 CN disclosed
WO-1991019700-A1 PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1991-12-26 WO disclosed
US-4971979-A Antiinflammatory agents RHONE-POULENC SANTE (FR) 1990-11-20 US disclosed
US-4886835-A ANTIINFLAMMATORY AGENTS RHONE-POULENC SANTE (FR) 1989-12-12 US disclosed
JP-H01249720-A SUPPOSITORY AMERICAN CYANAMID CO 1989-10-05 JP disclosed
US-4493844-A Insecticidal 2,2'-bridged(1,1'-biphenyl)-3-ylmethyl carboxamides FMC CORPORATION (US) 1985-01-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378224-B2 Heteroaryl compounds and their use as Mer inhibitors MERTK, RET, ERBB2 ABCC4 354/4885LMNA 1144/4885GAA 1225/4885
US-20050272905-A1 NOVEL POLY(ARALKYL KETONE)S AND METHODS OF PREPARING THE SAME ADSL, KHK, PKLR ABCC4 2849/4885LMNA 210/4885GAA 1268/4885
US-20250213560-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS HAVING PHENYL GROUP AND USES THEREOF PNMT, BDNF, NLN ABCC4 1904/4885LMNA 3008/4885GAA 666/4885
US-20250064941-A1 SIGLEC LIGANDS, CONJUGATES, AND METHODS OF USE THEREOF SIGLEC7, SIGLEC9, CD2BP2 ABCC4 3837/4885LMNA 2421/4885GAA 525/4885
US-20020032174-A1 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade TFPI, PLAT, TFPI2 ABCC4 1647/4885LMNA 689/4885GAA 1641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.