Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29663621 | 0.89 | RXFP1 (0.55) | RXFP1POLBLMNAKMT2AKDM4E | |
| SCHEMBL9330701 | 0.88 | KMT2A (0.61) | RXFP1POLBLMNAKMT2AKDM4E | |
| SCHEMBL12292165 | 0.86 | RXFP1 (0.53) | RXFP1POLBLMNAKMT2AKDM4E | |
| SCHEMBL15368377 | 0.83 | RXFP1 (0.59) | RXFP1POLBLMNAKMT2ANPC1 | |
| SCHEMBL29702265 | 0.83 | RXFP1 (0.55) | RXFP1POLBLMNAKMT2AKDM4E | |
| SCHEMBL29992092 | 0.83 | RXFP1 (0.59) | RXFP1POLBLMNAKMT2ANPC1 | |
| SCHEMBL222446 | 0.83 | RXFP1 (0.55) | RXFP1POLBLMNAKMT2AKDM4E | |
| SCHEMBL28493853 | 0.82 | KDM4E (0.60) | LMNAKMT2AKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL27969584 | 0.82 | HPGD (0.44) | RXFP1POLBKMT2ACYP1A2ALDH1A1 | |
| SCHEMBL2880191 | 0.82 | LMNA (0.54) | RXFP1POLBLMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104955826-A | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH | 2015-09-30 | — | — | CN | disclosed |