Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28034285 | 0.85 | REN (0.39) | RENPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2219018 | 0.85 | HTT (0.52) | RENPOLBTP53ALOX12HTT | |
| SCHEMBL28822499 | 0.82 | REN (0.47) | RENPOLBTP53ALOX12HTT | |
| SCHEMBL2221448 | 0.76 | CA1 (0.44) | RENPOLBTP53ALOX12HTT | |
| SCHEMBL2217094 | 0.75 | PTGS2 (0.46) | RENPOLBHTTALDH1A1L3MBTL1 | |
| SCHEMBL2221627 | 0.75 | PTGS2 (0.46) | RENPOLBTP53HTTSLC5A1 | |
| SCHEMBL2219586 | 0.75 | SMN1; SMN2 (0.47) | RENPOLBTP53HTTSMN1; SMN2 | |
| SCHEMBL2223484 | 0.75 | HSD11B1 (0.47) | RENTP53HTTRAB9ASMN1; SMN2 | |
| SCHEMBL2218506 | 0.75 | GAA (0.51) | RENHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2218858 | 0.75 | ALDH1A1 (0.43) | RENTP53HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103373985-B | Heterocyclic compounds and their use | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-10-28 | — | — | CN | disclosed |