SCHEMBL28036178

SCHEMBL28036178

O=C(N1CCC(c2ccc(F)cc2)CC1)N1CCC(c2ccc(F)cc2)CC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.55
NPC1 O15118 3/20 0.55
ATM Q13315 1/20 0.55
PARP10 Q53GL7 2/20 0.55
KCNH2 Q12809 1/20 0.53
HRH3 Q9Y5N1 1/20 0.53
MAPT P10636 2/20 0.52
CCR1 P32246 2/20 0.51
FAAH O00519 4/20 0.50
PARP14 Q460N5 2/20 0.48
TNKS O95271 1/20 0.48
PARP1 P09874 1/20 0.48
ALDH1A1 P00352 1/20 0.48
GAA P10253 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ADAMTS5 Q9UNA0 1/20 0.47
DRD2 P14416 1/20 0.47
CHRM4 P08173 1/20 0.46
HSD11B1 P28845 1/20 0.46
AKR1C3 P42330 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2636274 0.87 RAB9A (0.57) RAB9ANPC1ATMPARP10MAPT
SCHEMBL10460507 0.86 QDPR (0.62) RAB9ANPC1ATMPARP10KCNH2
SCHEMBL29072978 0.86 PARP10 (0.59) RAB9ANPC1ATMPARP10MAPT
SCHEMBL3099869 0.83 HSD11B1 (0.49) RAB9ANPC1ATMPARP10KCNH2
SCHEMBL7745919 0.82 FAAH (0.55) RAB9ANPC1ATMPARP10MAPT
SCHEMBL27888979 0.81 KCNH2 (0.73) RAB9ANPC1ATMKCNH2HRH3
SCHEMBL2937126 0.81 RAB9A (0.67) RAB9ANPC1ATMPARP10MAPT
SCHEMBL2937123 0.81 RAB9A (0.67) RAB9ANPC1ATMPARP10MAPT
SCHEMBL27629062 0.80 NPC1 (0.74) RAB9ANPC1ATMPARP10CCR1
SCHEMBL30693168 0.80 RAB9A (0.61) RAB9ANPC1ATMPARP10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104995173-A Nitrogen-containing heterocyclic compound KYOWA HAKKO KIRIN CO LTD 2015-10-21 CN disclosed