SCHEMBL28040389

SCHEMBL28040389

CC(C)(C)c1cc(C(C)(C)C)cc([Si]([C]2c3ccccc3-c3ccccc32)(c2cc(C(C)(C)C)cc(C(C)(C)C)c2)c2cc(C(C)(C)C)cc(C(C)(C)C)c2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.39
ALDH1A1 P00352 2/20 0.39
RAB9A P51151 2/20 0.39
PLA2G1B P04054 1/20 0.39
NFKB1 P19838 1/20 0.39
CASP3 P42574 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
NR2F2 P24468 1/20 0.32
POLB P06746 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28040359 0.79 PTAFR (0.34) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL28040419 0.74 ALDH1A1 (0.34) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL27870094 0.69 MEN1 (0.35) NPC1ALDH1A1RAB9APLA2G1BL3MBTL1
SCHEMBL28040839 0.69 METAP2 (0.34) NPC1RAB9APLA2G1BATG4BMEN1
SCHEMBL28040843 0.69 MAPT (0.39) NPC1ALDH1A1RAB9AL3MBTL1MAPT
SCHEMBL25700720 0.68 TACR1 (0.39) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL22936365 0.67 ALDH1A1 (0.33) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL12817721 0.67 GABRA1 (0.37) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL12817649 0.67 GABRA1 (0.37) NPC1ALDH1A1RAB9APLA2G1BNFKB1
SCHEMBL12817765 0.67 GABRA1 (0.37) NPC1ALDH1A1RAB9APLA2G1BNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed