Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27272343 | 0.84 | ALDH1A1 (0.50) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| Pyridine SCHEMBL28224545 | 0.79 | JAK2 (0.47) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| Acridine SCHEMBL4854060 | 0.76 | ALDH1A1 (0.68) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL28343144 | 0.76 | ALOX15 (0.58) | NPC1RAB9AMAPTMEN1KMT2A | |
| Benzophenone SCHEMBL30504146 | 0.72 | ALDH1A1 (0.62) | KDRNPC1RAB9AMAPTMEN1 | |
| Acridine SCHEMBL9644821 | 0.72 | ALDH1A1 (0.62) | KDRNPC1RAB9AMAPTMEN1 | |
| Benzil SCHEMBL9476443 | 0.72 | ALDH1A1 (0.62) | KDRNPC1RAB9AMAPTMEN1 | |
| Acridine SCHEMBL28228757 | 0.72 | ALDH1A1 (0.68) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2998471 | 0.72 | KDM4E (0.55) | KMT2ASMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL9131712 | 0.70 | CYP1A2 (0.46) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105481769-B | A kind of benzo (c) acridine derivatives and its preparation method and application | 广西中医药大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105476992-B | Application of the 2- methoxyl group -9- acridine benzamido thiocarbamides in acetylcholinesterase inhibitor is prepared | 广西中医药大学 | 2018-07-06 | — | — | CN | disclosed |
| CN-105399670-B | A kind of benzo (c) acridinium carboxamide base thiourea derivative and its preparation method and application | 广西中医药大学 | 2018-04-17 | — | — | CN | disclosed |
| CN-105418608-B | 7 benzos [b] [1,10] o-phenanthroline pyridinecarboxylic amido thiocarbamide and its production and use | 广西中医药大学 | 2017-11-14 | — | — | CN | disclosed |
| CN-105481769-A | Benzo(c)acridine derivative, and preparation method and use thereof | UNIV GUANGXI CHINESE MEDICINE | 2016-04-13 | — | — | CN | disclosed |
| CN-105418608-A | 7-benzo[b]-[1,10]o-phenanthroline pyridine carboxamide thiourea as well as preparation method and application thereof | UNIV GUANGXI CHINESE MEDICINE | 2016-03-23 | — | — | CN | disclosed |
| CN-105399670-A | Benzo[c]acridine amidothiourea derivative and preparation method and application thereof | UNIV GUANGXI CHINESE MEDICINE | 2016-03-16 | — | — | CN | disclosed |