Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.42 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27272343 | 0.90 | ALDH1A1 (0.50) | KCNK3CYP1A2ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL2998471 | 0.86 | KDM4E (0.55) | TYK2HTTCYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL28343144 | 0.80 | ALOX15 (0.58) | KCNK3CYP1A2ALDH1A1CYP3A4HPGD | |
| Acridine SCHEMBL28040645 | 0.79 | KDR (0.46) | HTTCYP1A2ALDH1A1CYP3A4CYP2C19 | |
| Benzoic Acid Hydrazide SCHEMBL5720780 | 0.75 | KDM4E (0.70) | JAK2TYK2NAMPTHTTKCNK3 | |
| SCHEMBL9131712 | 0.75 | CYP1A2 (0.46) | CYP1A2ALDH1A1CYP3A4CYP2C19KMT2A | |
| Pyridine SCHEMBL19329206 | 0.73 | ALDH1A1 (0.79) | JAK2TYK2CYP1A2ALDH1A1CYP2C9 | |
| Benzamide SCHEMBL1679183 | 0.73 | CYP3A4 (0.73) | JAK2TYK2CYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL28228905 | 0.73 | NOS3 (0.44) | ALDH1A1HPGDKMT2ATP53HDAC2 | |
| Pyridine SCHEMBL28224544 | 0.72 | CA1 (0.75) | JAK2TYK2ALDH1A1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105481769-B | A kind of benzo (c) acridine derivatives and its preparation method and application | 广西中医药大学 | 2018-07-10 | — | — | CN | disclosed |