SCHEMBL28040846

SCHEMBL28040846

Cc1cc(C)c([SiH2]c2ccccc2)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.40
CYP2A6 P11509 1/20 0.40
TSHR P16473 2/20 0.38
ACHE P22303 2/20 0.38
LMNA P02545 2/20 0.38
ALOX12 P18054 1/20 0.38
FFAR4 Q5NUL3 1/20 0.37
PSMB5 P28074 2/20 0.34
RAPGEF4 Q8WZA2 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
METAP2 P50579 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MCOLN3 Q8TDD5 1/20 0.31
C5AR1 P21730 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28040366 0.78 KDM4E (0.32) TSHRACHE
SCHEMBL28040349 0.78 ACHE (0.43) CYP1A2CYP2A6TSHRACHELMNA
SCHEMBL988389 0.77 KDM4E (0.34) TSHRACHELMNAALOX12
SCHEMBL12609408 0.77 RAPGEF4 (0.43) CYP1A2CYP2A6TSHRACHELMNA
SCHEMBL28040487 0.77 CYP1A2 (0.36) CYP1A2CYP2A6TSHRACHELMNA
Hydrochloric Acid SCHEMBL1033243 0.75 RAPGEF4 (0.41) CYP1A2CYP2A6TSHRACHELMNA
Ethylene SCHEMBL29078356 0.74 TSHR (0.39) TSHRACHELMNAALOX12SMN1; SMN2
SCHEMBL9319622 0.74 TDP1 (0.37) CYP1A2CYP2A6TSHRACHELMNA
SCHEMBL28278745 0.74 TSHR (0.44) CYP2A6TSHRACHELMNAALOX12
SCHEMBL52125 0.74 TSHR (0.44) CYP2A6TSHRACHELMNAALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed