SCHEMBL28040487

SCHEMBL28040487

Cc1cc(C)c(C)c([SiH2]c2ccccc2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
FFAR4 Q5NUL3 1/20 0.34
LMNA P02545 2/20 0.33
TSHR P16473 1/20 0.33
ALOX12 P18054 1/20 0.33
ACHE P22303 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
MCOLN3 Q8TDD5 1/20 0.32
PSMB5 P28074 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
RAB9A P51151 1/20 0.32
RAPGEF4 Q8WZA2 1/20 0.32
NR3C1 P04150 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31590141 0.82 KDM4E (0.32) TSHRACHEMEN1KMT2AKDM4E
SCHEMBL28823591 0.82 KDM4E (0.32) TSHRACHEMEN1KMT2AKDM4E
SCHEMBL9319622 0.78 TDP1 (0.37) CYP1A2CYP2A6LMNATSHRALOX12
SCHEMBL28040846 0.77 CYP1A2 (0.40) CYP1A2CYP2A6FFAR4LMNATSHR
SCHEMBL989764 0.75 TRPA1 (0.38) CYP1A2CYP2A6LMNATSHRALOX12
SCHEMBL28040349 0.73 ACHE (0.43) CYP1A2CYP2A6FFAR4LMNATSHR
SCHEMBL27871135 0.73
SCHEMBL28040867 0.72 TSHR (0.37) CYP1A2CYP2A6LMNATSHRALOX12
SCHEMBL988389 0.72 KDM4E (0.34) LMNATSHRALOX12ACHEMEN1
SCHEMBL28040456 0.72 TSHR (0.33) LMNATSHRALOX12ACHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed