Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NNMT | P40261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22658874 | 0.85 | L3MBTL1 (0.45) | L3MBTL1POLBALDH1A1KDM4ERAB9A | |
| SCHEMBL29587479 | 0.85 | L3MBTL1 (0.45) | L3MBTL1POLBALDH1A1KDM4ERAB9A | |
| SCHEMBL28045757 | 0.84 | TDP1 (0.66) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL7902874 | 0.80 | POLB (0.51) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL2473278 | 0.80 | NPC1 (0.43) | L3MBTL1ALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL21041119 | 0.80 | NNMT (0.69) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL11605385 | 0.80 | TDP1 (0.71) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL30527055 | 0.79 | POLB (0.47) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL21041142 | 0.79 | POLB (0.47) | L3MBTL1POLBTDP1NNMTALDH1A1 | |
| SCHEMBL23970964 | 0.79 | TUBB4A (0.51) | L3MBTL1ALDH1A1KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |