Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831107 | 0.87 | CNR2 (0.57) | CNR2ALDH1A1ITGB3ITGA2BCTSB | |
| SCHEMBL9831110 | 0.87 | CNR2 (0.57) | CNR2ALDH1A1ITGB3ITGA2BCTSB | |
| SCHEMBL10660589 | 0.81 | ALDH1A1 (0.51) | CNR2ALDH1A1MAPK1L3MBTL1CASP1 | |
| SCHEMBL13819263 | 0.81 | ACE (0.63) | CNR2ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL18775036 | 0.81 | CTSK (0.57) | ALDH1A1CTSBCTSLCTSSPSMB8 | |
| SCHEMBL18791070 | 0.81 | CTSK (0.57) | ALDH1A1CTSBCTSLCTSSPSMB8 | |
| SCHEMBL24339778 | 0.80 | FOLH1 (0.48) | CTSBNAALAD2 | |
| SCHEMBL7347418 | 0.80 | CASP1 (0.60) | CNR2ALDH1A1MAPK1L3MBTL1CASP1 | |
| SCHEMBL28045721 | 0.78 | FOLH1 (0.63) | CNR2ITGB3ITGA2BCTSBCTSL | |
| SCHEMBL28045720 | 0.78 | FOLH1 (0.63) | CNR2ITGB3ITGA2BCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105175418-B | Pentacyclic indole quinolizine for inhibiting autophagy of cells, synthesis, antitumor activity and application thereof | 首都医科大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-105175418-A | Pentacyclic indole quinolizine inhibiting cell autophagy, synthesis, antitumor activity and application thereof | UNIV CAPITAL MEDICAL SCIENCES | 2015-12-23 | — | — | CN | disclosed |