Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28929394 | 0.90 | TRPV6 (0.45) | HPGDTSHRTP53MDM2ALDH1A1 | |
| SCHEMBL28007890 | 0.78 | MAPT (0.41) | MAPTSIGMAR1 | |
| SCHEMBL27906284 | 0.77 | TACR1 (0.41) | S1PR1SIGMAR1 | |
| SCHEMBL27866895 | 0.77 | MAPT (0.43) | MAPTDRD2DRD1DRD3 | |
| SCHEMBL27538076 | 0.76 | SLC18A3 (0.44) | SIGMAR1 | |
| SCHEMBL7446705 | 0.76 | MAPT (0.42) | MAPTSIGMAR1 | |
| SCHEMBL12604444 | 0.76 | BRD4 (0.38) | HPGDTSHRMAPTALDH1A1POLB | |
| SCHEMBL9980195 | 0.76 | BRD4 (0.38) | HPGDTSHRMAPTALDH1A1POLB | |
| SCHEMBL8134221 | 0.75 | DRD2 (0.44) | HPGDTSHRMAPTSIGMAR1DRD2 | |
| SCHEMBL27889765 | 0.75 | DRD4 (0.40) | HPGDALDH1A1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209457-A | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBVIE DEUTSCHLAND | 2015-12-30 | — | — | CN | disclosed |