Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27934873 | 0.71 | HPGD (0.46) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL28080836 | 0.70 | F2RL3 (0.39) | BRD4ALDH1A1LMNABRD2BRD3 | |
| SCHEMBL28905120 | 0.69 | GAA (0.41) | ALDH1A1LMNAMEN1KMT2AEGLN1 | |
| SCHEMBL27704041 | 0.67 | BRD4 (0.39) | BRD4BRD2BRD3BRDT | |
| SCHEMBL28080903 | 0.67 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNAPOLBMEN1 | |
| SCHEMBL27721655 | 0.66 | ADRA1D (0.41) | HDAC1HDAC8HDAC6ALDH1A1POLB | |
| SCHEMBL28829351 | 0.65 | FLT1 (0.60) | ALDH1A1KDM4EMAPT | |
| SCHEMBL27770330 | 0.65 | CHRM1 (0.43) | HDAC8HDAC6LMNA | |
| SCHEMBL10349900 | 0.64 | CNR2 (0.52) | BRD4HDAC8HDAC6ALDH1A1KDM4E | |
| SCHEMBL28716413 | 0.64 | ACHE (0.37) | BRD4BRD2BRD3BRDTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209457-A | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBVIE DEUTSCHLAND | 2015-12-30 | — | — | CN | disclosed |