Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 3/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 2/20 | 0.30 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352651 | 0.83 | CYP4F2 (0.40) | IDO1TSHRPRMT6EPHX2PPARG | |
| SCHEMBL28047740 | 0.83 | PRKCI (0.49) | FYNPRKCICDK8 | |
| SCHEMBL1031072 | 0.77 | IDO1 (0.50) | IDO1TSHRNOTUM | |
| SCHEMBL4830146 | 0.74 | HSD17B1 (0.58) | FYNHSD17B1HSD17B2 | |
| SCHEMBL4013546 | 0.74 | IDO1 (0.50) | IDO1TSHRPPARG | |
| SCHEMBL6948234 | 0.74 | METAP2 (0.50) | TSHR | |
| SCHEMBL1310731 | 0.73 | TSHR (0.48) | TSHRPRMT6EPHX2HRH3PRKCI | |
| SCHEMBL1520375 | 0.72 | RAB9A (0.43) | IDO1TSHRNOTUM | |
| Ammonia Solution, Strong SCHEMBL27708939 | 0.70 | RAB9A (0.42) | IDO1TSHRNOTUM | |
| SCHEMBL24921144 | 0.70 | TDO2 (0.51) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189446-B | Phloroglucin analog derivative and its purposes in treating neurodegenerative disease | 中国医学科学院药物研究所 | 2018-07-20 | — | — | CN | disclosed |
| CN-105189446-A | Phloroglucinol derivatives and application thereof in treatment of neurodegenerative disorder | INST MATERIA MEDICA CAMS | 2015-12-23 | — | — | CN | disclosed |