Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20414976 | 0.84 | ALDH1A1 (0.41) | LMNAMAPK1ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL384463 | 0.77 | MAPT (0.36) | MAPK1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14675935 | 0.76 | KDM4E (0.42) | LMNAALDH1A1MAPTTDP1TP53 | |
| SCHEMBL15993007 | 0.76 | POLB (0.43) | ALDH1A1MAPTHTTRAB9AGSK3A | |
| SCHEMBL23884741 | 0.75 | ALDH1A1 (0.49) | MAPK1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13876041 | 0.75 | HRH3 (0.42) | ALDH1A1TP53RAB9APOLBKDM4E | |
| Bromide SCHEMBL1887327 | 0.74 | DHFR (0.34) | LMNAALDH1A1MAPTTP53NPC1 | |
| SCHEMBL4625962 | 0.73 | RAB9A (0.45) | LMNAALDH1A1MAPTNPC1RAB9A | |
| Iodide SCHEMBL4213036 | 0.73 | HRH3 (0.41) | ALDH1A1TP53RAB9APOLBKDM4E | |
| SCHEMBL18807591 | 0.72 | MGLL (0.44) | LMNAMAPK1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989164-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110062761-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-105189506-A | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG | 2015-12-23 | — | — | CN | disclosed |
| CN-101903381-A | Novel compound having affinity for amyloid | NIHON MEDIPHYSICS CO LTD | 2010-12-01 | — | — | CN | disclosed |