Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445568 | 0.94 | — | — | |
| SCHEMBL29695082 | 0.94 | — | — | |
| Formic Acid SCHEMBL28048184 | 0.83 | NFE2L2 (0.49) | NFE2L2PLAUNPC1L3MBTL1POLB | |
| Formic Acid Methyl Ester SCHEMBL27958586 | 0.83 | NFE2L2 (0.49) | NFE2L2PLAUPDGFRBPDGFRANPC1 | |
| SCHEMBL11544019 | 0.81 | L3MBTL1 (0.48) | NFE2L2PLAUNPC1L3MBTL1POLB | |
| SCHEMBL20406217 | 0.77 | POLB (0.50) | NFE2L2NPC1L3MBTL1POLBRAB9A | |
| SCHEMBL16586557 | 0.76 | LMNA (0.43) | NFE2L2NPC1POLBRAB9AMEN1 | |
| Cyanide SCHEMBL28298857 | 0.76 | PLAU (0.43) | NFE2L2PLAUPDGFRBPDGFRANPC1 | |
| SCHEMBL1415473 | 0.76 | ALDH1A1 (0.49) | NFE2L2NPC1L3MBTL1POLBRAB9A | |
| SCHEMBL7055873 | 0.75 | L3MBTL1 (0.44) | NFE2L2NPC1L3MBTL1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164121-A | Perfluorinated cyclopropyl-fused 1, 3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use thereof | AMGEN INC | 2015-12-16 | — | — | CN | disclosed |