Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28808109 | 0.80 | CYP3A4 (0.39) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL27080876 | 0.78 | ALDH1A1 (0.36) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL8439769 | 0.78 | LMNA (0.34) | LMNAALDH1A1HPGDF2GLA | |
| Methylamine SCHEMBL536416 | 0.76 | KDM4E (0.41) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL1291212 | 0.75 | KDM4E (0.43) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL22557537 | 0.74 | KDM4E (0.44) | CYP19A1CTSLCTSBLMNAALDH1A1 | |
| SCHEMBL28048187 | 0.74 | POLB (0.40) | LMNAALDH1A1POLBMAPTPKM | |
| SCHEMBL6677424 | 0.73 | LMNA (0.37) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL12471969 | 0.71 | LMNA (0.35) | LMNAALDH1A1HPGDF2GLA | |
| SCHEMBL25183271 | 0.70 | NFKB1 (0.35) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164121-A | Perfluorinated cyclopropyl-fused 1, 3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use thereof | AMGEN INC | 2015-12-16 | — | — | CN | disclosed |