Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9380769 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL27676453 | 0.87 | TSHR (0.40) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL4928444 | 0.83 | TSHR (0.36) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL11226261 | 0.83 | HCAR2 (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL3878187 | 0.83 | HCAR2 (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL16466651 | 0.83 | HCAR2 (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL1116590 | 0.82 | HCAR2 (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL1116591 | 0.82 | HCAR2 (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL29110380 | 0.82 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27407467 | 0.82 | ALDH1A1 (0.53) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102149523-B | Method for producing conglomerate stone articles comprising the use of peroxide initiators | Luca Tonchley (IT) | 2015-08-19 | — | — | CN | claimed |
| US-8435424-B2 | Solvent-free conductive paste composition and solar cell element employing the same | ETERNAL CHEMICAL CO., LTD. (TW) | 2013-05-07 | — | — | US | claimed |
| CN-102898962-A | Dual-curing adhesive composition | ETERNAL CHEMICAL INDUSTRY CO LTD | 2013-01-30 | — | — | CN | claimed |
| CN-102149523-A | Method for producing conglomerate stone articles comprising the use of peroxide initiators | TONCELLI LUCA | 2011-08-10 | — | — | CN | claimed |
| US-20100186823-A1 | SOLVENT-FREE CONDUCTIVE PASTE COMPOSITION AND SOLAR CELL ELEMENT EMPLOYING THE SAME | ETERNAL CHEMICAL CO., LTD. | 2010-07-29 | — | — | US | claimed |
| CN-119731284-A | Adhesive composition, adhesive layer, adhesive sheet, optical member with adhesive layer, image display device, and touch panel | 日东电工株式会社 | 2025-03-28 | — | — | CN | disclosed |
| CN-119432246-A | Optical adhesive sheet | 日东电工株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-119432248-A | Optical adhesive sheet | 日东电工株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-119432247-A | Optical adhesive sheet | 日东电工株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-119161823-A | Pressure-sensitive adhesive sheet, optical member with pressure-sensitive adhesive layer, and image display device | 日东电工株式会社 | 2024-12-20 | — | — | CN | disclosed |
| CN-112996839-A | Material for forming film for lithography, composition for forming film for lithography, underlayer film for lithography, and pattern formation method | 三菱瓦斯化学株式会社 | 2021-06-18 | — | — | CN | disclosed |
| CN-107567473-A | Injection molding rubber composition | 和仁化学株式会社 | 2018-01-09 | — | — | CN | disclosed |
| US-5260164-A | Silver halide, organic silver salt, cyclic reducing agent, the above compounds adapted to provide imagewise oxidized product of reducing agent upon imagewise exposure and heat development, polymer precursor, photopolymerization initiator | CANON KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5114990-A | Olefin polymerization with inorganic oxide pigments in the presence of an olefin catalyst | FELIX SCHOELLER JR. GMBH KG (DE) | 1992-05-19 | — | — | US | disclosed |
| US-5064744-A | Heat, photopolymerization, silver halide contrast | CANON KABUSHIKI KAISHA (JP) | 1991-11-12 | — | — | US | disclosed |
| EP-0358388-A2 | Composition for polymerization with improved activator system | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0356253-A2 | Polymerization process for methyl methacrylate with improved activator system | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-28 | — | — | EP | disclosed |
| EP-0330504-A2 | Photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-30 | — | — | EP | disclosed |
| US-4839324-A | MALEIC ACID PERESTER SALT AND BISULFITE; POLYMETHYL METHACRYLATE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-06-13 | — | — | US | disclosed |
| US-4831093-A | PERESTER SALT OF MALEIC ACID AND BISULFITE IN WATER-IN-OIL EMULSION | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-05-16 | — | — | US | disclosed |