Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512809 | 0.85 | SAE1 (0.51) | HTTEGFRLCKRXFP1KDM4E | |
| SCHEMBL13763602 | 0.80 | TRPA1 (0.62) | EGFRLCKCSF1RFLT4TRPA1 | |
| SCHEMBL13783329 | 0.76 | RXFP1 (0.49) | HTTSMN1; SMN2RXFP1STAT1KDM4E | |
| SCHEMBL401110 | 0.75 | PDE4A (0.57) | HTTSMN1; SMN2RXFP1KDM4EALDH1A1 | |
| SCHEMBL29416410 | 0.75 | PDE4A (0.57) | HTTSMN1; SMN2RXFP1KDM4EALDH1A1 | |
| SCHEMBL30117773 | 0.73 | RAB9A (0.56) | HTTEGFRSMN1; SMN2RXFP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5739823 | 0.73 | PDE4A (0.55) | HTTSMN1; SMN2RXFP1KDM4EALDH1A1 | |
| SCHEMBL7053228 | 0.73 | RAB9A (0.56) | HTTEGFRSMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL1702115 | 0.73 | LMNA (0.61) | SMN1; SMN2RXFP1ALDH1A1MAPK1SRC | |
| SCHEMBL4417636 | 0.72 | NR4A2 (0.47) | HTTSMN1; SMN2RXFP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294578-A | Quinazoline derivative having targeted antitumor activity | GUANGDONG WHOLEWIN TECHNOLOGY CO LTD | 2016-02-03 | — | — | CN | disclosed |