SCHEMBL28050310

SCHEMBL28050310

CC(C)(C)C(=O)ON1CCN(C(=O)c2cnc(N)cn2)CC1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 18/20 0.38
HRH3 Q9Y5N1 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27861424 0.81 RAB9A (0.43) TRPC6HRH3
SCHEMBL28050305 0.79 RAB9A (0.37) HRH3
SCHEMBL27915910 0.78 L3MBTL1 (0.40) TRPC6HRH3
SCHEMBL27874881 0.75 L3MBTL1 (0.66)
SCHEMBL27964361 0.75 TRPC6 (0.36) TRPC6
SCHEMBL27820419 0.73 POLB (0.36) HRH3
SCHEMBL27751339 0.73 CA12 (0.51)
SCHEMBL27722335 0.73 TRPC6 (0.44) TRPC6
SCHEMBL28289049 0.71 ALDH1A1 (0.50)
SCHEMBL28872461 0.69 TDP1 (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105294737-B The compound and application thereof of CDK type small molecular inhibitor 广东东阳光药业有限公司 2019-02-12 CN disclosed
CN-105294737-A Compound of CDK small-molecule inhibitor and application thereof GUANGDONG HEC PHARMACEUTICAL 2016-02-03 CN disclosed