Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400739 | 0.82 | POLB (0.53) | CFTRPOLBNR1H2 | |
| SCHEMBL27874881 | 0.81 | L3MBTL1 (0.66) | L3MBTL1SMN1; SMN2GAARBP4 | |
| SCHEMBL3401608 | 0.79 | HRH4 (0.50) | L3MBTL1CFTRSMN1; SMN2POLBHRH3 | |
| SCHEMBL27853340 | 0.78 | CA12 (0.53) | LMNASMN1; SMN2GAA | |
| SCHEMBL28050310 | 0.78 | TRPC6 (0.38) | HRH3TRPC6 | |
| SCHEMBL27934400 | 0.77 | KDM5C (0.40) | L3MBTL1LMNAPOLB | |
| SCHEMBL27751339 | 0.77 | CA12 (0.51) | LMNASMN1; SMN2HSD17B10POLB | |
| SCHEMBL27820419 | 0.77 | POLB (0.36) | L3MBTL1CFTRLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL28289049 | 0.75 | ALDH1A1 (0.50) | L3MBTL1LMNASMN1; SMN2POLBGAA | |
| SCHEMBL28050305 | 0.74 | RAB9A (0.37) | LMNASMN1; SMN2HSD17B10HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |