Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28252478 | 0.88 | TAS2R14 (0.56) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL697951 | 0.86 | TAS2R14 (0.67) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL12327907 | 0.86 | TAS2R14 (0.54) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL29656425 | 0.86 | TAS2R14 (0.54) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL29629424 | 0.85 | TAS2R14 (0.53) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL2576656 | 0.85 | TAS2R14 (0.53) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL5370256 | 0.85 | TAS2R14 (0.53) | TAS2R14CTSSDHODHHDAC6LMNA | |
| Hydrochloric Acid SCHEMBL15352107 | 0.85 | TAS2R14 (0.65) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL25112416 | 0.82 | CTSS (0.51) | TAS2R14CTSSDHODHHDAC6LMNA | |
| SCHEMBL29656616 | 0.82 | CTSS (0.51) | TAS2R14CTSSDHODHHDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003200-A | P2X7 regulator | 詹森药业有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-105209464-B | P2X7 modulators | 詹森药业有限公司 | 2019-01-01 | — | — | CN | claimed |
| CN-105209464-A | P2x7 modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | claimed |
| CN-110003200-A | P2X7 regulator | 詹森药业有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105209464-B | P2X7 modulators | 詹森药业有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-105209464-A | P2x7 modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |