Sugi Predict

Sugi Predict / Compounds / SCHEMBL5370256

SCHEMBL5370256

SCHEMBL5370256

Cc1c(C(=O)Cl)cccc1C(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TAS2R14 Q9NYV8 2/20 0.53
▸ CTSS P25774 4/20 0.50
▸ DHODH Q02127 1/20 0.46
▸ HDAC6 Q9UBN7 1/20 0.46
▸ LMNA P02545 1/20 0.44
▸ GAA P10253 1/20 0.44
▸ ALDH1A1 P00352 2/20 0.42
▸ ALOX15 P16050 1/20 0.42
▸ P2RX7 Q99572 4/20 0.41
▸ CNR1 P21554 1/20 0.41
▸ CNR2 P34972 1/20 0.41
▸ CTSK P43235 2/20 0.40
▸ KCNK3 O14649 1/20 0.40
▸ KCNK9 Q9NPC2 1/20 0.40
▸ ALOX12 P18054 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28052031 0.85 TAS2R14 (0.55) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL697951 0.83 TAS2R14 (0.67) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL12327907 0.83 TAS2R14 (0.54) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL29656425 0.83 TAS2R14 (0.54) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL29629424 0.81 TAS2R14 (0.53) TAS2R14CTSSDHODHHDAC6LMNA
Hydrochloric Acid SCHEMBL15352107 0.81 TAS2R14 (0.65) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL2576656 0.81 TAS2R14 (0.53) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL27976262 0.81 TAS2R14 (0.49) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL16093935 0.81 CTSS (0.60) TAS2R14CTSSDHODHHDAC6LMNA
SCHEMBL24201 0.80 LMNA (0.60) TAS2R14LMNAGAAALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12338243-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-06-24 — — US disclosed
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 — — US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20220235062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-28 — — US disclosed
WO-2022156788-A1 BENZIMIDAZOLE COMPOUND AND USE THEREOF 武汉人福创新药物研发中心有限公司 2022-07-28 — — WO disclosed
CN-114773331-A Benzimidazole compounds and uses thereof 武汉人福创新药物研发中心有限公司 2022-07-22 — — CN disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 — — US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 — — US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 — — US disclosed
WO-2013162077-A1 TETRAZOLINONE COMPOUNDS AND ITS USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-10-31 — — WO disclosed
WO-2013162072-A1 TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-10-31 — — WO disclosed
CN-100372838-C Piperidine-benzenesulfonamide derivatives HOFFMANN LA ROCHE (CH) 2008-03-05 — — CN disclosed
US-7176316-B2 Amino-piperidine derivatives HOFFMANN-LA ROCHE INC. (US) 2007-02-13 — — US disclosed
EP-1594840-B1 PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES HOFFMANN LA ROCHE (CH) 2006-09-27 — — EP disclosed
CN-1751023-A Piperidine-benzenesulfonamide derivatives HOFFMANN LA ROCHE (CH) 2006-03-22 — — CN disclosed
EP-1594840-A1 PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2005-11-16 — — EP disclosed
WO-2004072034-A1 PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2004-08-26 — — WO disclosed
US-20040167166-A1 Amino-piperidine derivatives HOFFMANN-LA ROCHE INC. 2004-08-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220235062-A1 P2X7 MODULATORS P2RX7, P2RX4, P2RX1 TAS2R14 2157/4885CTSS 2298/4885DHODH 1573/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 TAS2R14 2225/4885CTSS 2569/4885DHODH 3071/4885
US-12338243-B2 P2X7 modulators P2RX7, P2RX4, P2RX1 TAS2R14 2157/4885CTSS 2298/4885DHODH 1573/4885
US-20040167166-A1 Amino-piperidine derivatives OPRL1, GRIA1, GRIN1 TAS2R14 3941/4885CTSS 3379/4885DHODH 1707/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 TAS2R14 2225/4885CTSS 2569/4885DHODH 3071/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 TAS2R14 2225/4885CTSS 2569/4885DHODH 3071/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 TAS2R14 2225/4885CTSS 2569/4885DHODH 3071/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 TAS2R14 2225/4885CTSS 2569/4885DHODH 3071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.