Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28052170 | 0.77 | KLKB1 (0.35) | KLKB1 | |
| SCHEMBL28825964 | 0.71 | CHRNB2 (0.32) | — | |
| SCHEMBL28052255 | 0.67 | KLKB1 (0.36) | KLKB1 | |
| SCHEMBL17229326 | 0.65 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL16247156 | 0.65 | KLKB1 (0.59) | KLKB1 | |
| SCHEMBL16486803 | 0.64 | KLKB1 (0.48) | KLKB1RAB9ASMN1; SMN2 | |
| SCHEMBL16246833 | 0.64 | KLKB1 (0.56) | KLKB1NPC1 | |
| SCHEMBL17685596 | 0.63 | NPC1 (0.74) | KLKB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15759268 | 0.63 | KLKB1 (0.51) | KLKB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26946141 | 0.62 | GABRA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452240-A | Heterocyclic derivates | KALVISTA PHARMACEUTICALS LTD | 2016-03-30 | — | — | CN | disclosed |