Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | LIPE | Q05469 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15878542 | 0.90 | TDP1 (0.55) | MAPTGAATDP1NPC1RAB9A | |
| SCHEMBL29589853 | 0.88 | SMN1; SMN2 (0.59) | MAPTGAATDP1NPC1RAB9A | |
| SCHEMBL15355311 | 0.88 | SMN1; SMN2 (0.59) | MAPTGAATDP1NPC1RAB9A | |
| SCHEMBL29591000 | 0.86 | RAB9A (0.59) | MAPTNPC1RAB9ALIPENOTUM | |
| SCHEMBL28826015 | 0.86 | LIPE (0.62) | MAPTGAATDP1LIPENOTUM | |
| SCHEMBL29560919 | 0.86 | L3MBTL1 (0.66) | MAPTGAATDP1NPC1RAB9A | |
| SCHEMBL29698174 | 0.82 | HPGD (0.68) | MAPTNPC1RAB9APDE4BMEN1 | |
| SCHEMBL13647708 | 0.82 | HPGD (0.54) | MAPTGAATDP1NPC1RAB9A | |
| SCHEMBL8247508 | 0.82 | HPGD (0.68) | MAPTNPC1RAB9APDE4BMEN1 | |
| SCHEMBL28825992 | 0.80 | RAB9A (0.62) | MAPTGAANPC1RAB9ALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431422-A | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2016-03-23 | — | — | CN | disclosed |