Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.43 |
| ▸ | S100A9 | P06702 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053322 | 0.78 | APLNR (0.51) | APLNRPTGS2PTGS1PIK3CGPIK3CD | |
| SCHEMBL1775244 | 0.75 | APLNR (0.59) | APLNRPTGS2PTGS1S100A9PIK3CG | |
| SCHEMBL28053340 | 0.74 | PTGS1 (0.42) | APLNRPTGS2PTGS1S100A9PTGES2 | |
| SCHEMBL6069906 | 0.72 | PTGS2 (0.63) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL28053243 | 0.71 | APLNR (0.47) | APLNRPTGS2PIK3CGPIK3CDSCN10A | |
| SCHEMBL6069927 | 0.71 | PTGS2 (0.49) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5989061 | 0.70 | CYP2A6 (0.50) | PTGS2PTGS1 | |
| SCHEMBL11690551 | 0.69 | APLNR (0.71) | APLNRPIK3CGPIK3CDCA1CA2 | |
| SCHEMBL18247080 | 0.68 | APLNR (1.00) | APLNRPTGS2PTGS1PIK3CGPIK3CD | |
| SCHEMBL28053342 | 0.68 | PTGS1 (0.36) | PTGS2PTGS1S100A9CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |