Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 7/20 | 0.36 |
| ▸ | CA2 | P00918 | 7/20 | 0.36 |
| ▸ | CA9 | Q16790 | 6/20 | 0.36 |
| ▸ | VRK2 | Q86Y07 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053327 | 0.89 | APLNR (0.45) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053258 | 0.78 | PKM (0.46) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053345 | 0.78 | APLNR (0.50) | APLNRPIK3CGPIK3CDPTGS1PTGS2 | |
| SCHEMBL28053242 | 0.77 | APLNR (0.43) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053347 | 0.75 | CA1 (0.44) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053374 | 0.74 | LRRK2 (0.44) | APLNRPIK3CGPIK3CDPTGS1PTGS2 | |
| SCHEMBL28826183 | 0.74 | APLNR (0.40) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053239 | 0.72 | APLNR (0.38) | APLNRPTGS1PTGS2CA1CA2 | |
| SCHEMBL28053310 | 0.72 | SCN10A (0.44) | APLNRCA1CA2CA9CA12 | |
| SCHEMBL28826194 | 0.70 | SOS1 (0.39) | APLNRCA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |