Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | VRK2 | Q86Y07 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053271 | 0.74 | PTGS2 (0.37) | APLNRPTGS2MAP4K4PIK3CAKCNH2 | |
| SCHEMBL28053345 | 0.71 | APLNR (0.50) | APLNRPTGS2PIK3CAPIK3CDPIK3CG | |
| SCHEMBL28053322 | 0.70 | APLNR (0.51) | APLNRPTGS2PIK3CDPIK3CGVRK2 | |
| SCHEMBL30313919 | 0.69 | APLNR (0.53) | APLNRPTGS2KIF11CHRNA7SCN10A | |
| SCHEMBL13742956 | 0.69 | KIF11 (0.49) | APLNRPTGS2PIK3CDPIK3CGKIF11 | |
| SCHEMBL20187860 | 0.68 | PTGS2 (0.51) | APLNRPTGS2PIK3CDPIK3CG | |
| SCHEMBL2169084 | 0.68 | TRPV4 (0.52) | PTGS2MAP4K4PIK3CAKCNH2MINK1 | |
| SCHEMBL30845950 | 0.68 | TRPV4 (0.52) | PTGS2MAP4K4PIK3CAKCNH2MINK1 | |
| SCHEMBL30580593 | 0.68 | PTGS2 (0.50) | APLNRPTGS2KCNH2PIK3CDPIK3CG | |
| SCHEMBL31181562 | 0.67 | APLNR (0.52) | APLNRPTGS2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-B | N (heteroaryl) sulfamide derivative as S100 inhibitor | 活跃生物技术有限公司 | 2017-08-04 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-B | N (heteroaryl) sulfamide derivative as S100 inhibitor | 活跃生物技术有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |