Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27524153 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HPGDELANELMNAHTT | |
| SCHEMBL14130437 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HPGDELANELMNAHTT | |
| Bromide SCHEMBL29044663 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDELANELMNAHTT | |
| Bicarbonate SCHEMBL28038338 | 0.72 | ALDH1A1 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL14997833 | 0.72 | ELANE (0.50) | ALDH1A1HPGDELANEHTTRAB9A | |
| Hydrochloric Acid SCHEMBL9350965 | 0.72 | ELANE (0.50) | ALDH1A1HPGDELANEHTTRAB9A | |
| Bromide SCHEMBL4904449 | 0.71 | ELANE (0.49) | ALDH1A1HPGDELANEHTTRAB9A | |
| SCHEMBL28502490 | 0.71 | ALDH1A1 (0.49) | ALDH1A1HPGDELANELMNAHTT | |
| Hydrochloric Acid SCHEMBL28287172 | 0.71 | ALDH1A1 (0.42) | ALDH1A1HPGDELANELMNAHTT | |
| Hydrochloric Acid SCHEMBL21638 | 0.71 | ALDH1A1 (0.54) | ALDH1A1HTTSMN1; SMN2L3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107530231-A | Low viscosity hair care compositions | 宝洁公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-107072934-A | Personal care compositions and methods of preparation | 宝洁公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-105307726-A | Amphoteric ter-polymers for use in personal care compositions | PROCTER & GAMBLE | 2016-02-03 | — | — | CN | disclosed |