Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Sulfide SCHEMBL28207719 | 0.94 | ALDH1A1 (0.50) | ALDH1A1SIGMAR1OPRK1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL28000297 | 0.83 | MEN1 (0.36) | MEN1KMT2ASIGMAR1HPGDOPRK1 | |
| Acetic Acid SCHEMBL27962332 | 0.81 | MEN1 (0.36) | MEN1KMT2ASIGMAR1HPGDOPRK1 | |
| Acetic Acid SCHEMBL8076704 | 0.77 | MEN1 (0.36) | MEN1KMT2ASIGMAR1HPGDOPRK1 | |
| Hydrogen Sulfide SCHEMBL28137593 | 0.76 | SIGMAR1 (0.38) | ALDH1A1SIGMAR1OPRK1CYP1A2CYP2D6 | |
| SCHEMBL27836103 | 0.74 | SIGMAR1 (0.39) | ALDH1A1SIGMAR1OPRK1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL27982197 | 0.73 | ANPEP (0.46) | ALDH1A1MEN1KMT2ASIGMAR1OPRK1 | |
| Acetic Acid SCHEMBL28995037 | 0.70 | ANPEP (0.40) | ALDH1A1MEN1KMT2ASIGMAR1OPRK1 | |
| Benzyl Isothiocyanate SCHEMBL28996243 | 0.68 | MIF (0.49) | ALDH1A1SIGMAR1HPGDTP53CYP1A2 | |
| SCHEMBL5577576 | 0.67 | SIGMAR1 (0.70) | SIGMAR1OPRK1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110066341-A | proteins, conjugates, pharmaceutical compositions, DNA constructs, host cells, and methods of making human SIRP α fusion proteins | 特里姆治疗公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-105722534-B | In conjunction with the antibody drug conjugates (ADC) of CD37 albumen | 艾更斯司股份有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-105073780-B | Treatment of CD47+ disease cells with SIRP α -Fc fusion protein | 特里姆治疗公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-105722534-A | Antibody drug conjugates (ADC) that bind to CD37 proteins | 艾更斯司股份有限公司 | 2016-06-29 | — | — | CN | disclosed |