Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28005843 | 0.80 | REN (0.42) | G6PC1NPC1RAB9ACA12CA9 | |
| Acetic Acid SCHEMBL27771245 | 0.79 | CARM1 (0.45) | MEN1KMT2AG6PC1NPC1RAB9A | |
| Acetic Acid SCHEMBL28054127 | 0.77 | ALDH1A1 (0.44) | MEN1KMT2ASLC2A1SIGMAR1HPGD | |
| Acetic Acid SCHEMBL28850624 | 0.76 | REN (0.39) | SIGMAR1G6PC1NPC1RAB9ACA12 | |
| Benzyl Isothiocyanate SCHEMBL28996243 | 0.75 | MIF (0.49) | SIGMAR1HPGDTP53CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL27962332 | 0.75 | MEN1 (0.36) | MEN1KMT2ASLC2A1SIGMAR1HPGD | |
| Acetic Acid SCHEMBL28000297 | 0.74 | MEN1 (0.36) | MEN1KMT2ASLC2A1SIGMAR1HPGD | |
| Acetic Acid SCHEMBL28964371 | 0.72 | KEAP1 (0.39) | MEN1KMT2ASIGMAR1NPC1RAB9A | |
| SCHEMBL7061213 | 0.71 | MAOA (0.39) | SIGMAR1HPGDG6PC1 | |
| Acetic Acid SCHEMBL28995037 | 0.71 | ANPEP (0.40) | MEN1KMT2ASIGMAR1OPRK1ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156893-A | Anti-cd 3 antibodies and application method | 基因泰克公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-106029696-A | anti-CD 3 antibodies and methods of use | 基因泰克公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-1047457-A2 | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE | MCA Development B.V. (NL) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036105-A9 | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE | MCA DEV B V (NL) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999036105-A2 | USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE | MCA DEVELOPMENT B.V. (NL) | 1999-07-22 | — | — | WO | disclosed |