Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.41 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28056298 | 0.84 | AKR1B1 (0.51) | KDM4EALDH1A1TTRAKR1B1HSD17B10 | |
| SCHEMBL28056374 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL9890641 | 0.74 | CXCL8 (0.57) | NR4A2KDM4EALDH1A1RXFP1CXCL8 | |
| SCHEMBL6545903 | 0.73 | ALDH1A1 (0.47) | KDM4EALDH1A1DPP4HSD17B10KMT2A | |
| SCHEMBL11258381 | 0.72 | TDP1 (0.48) | NR4A2KDM4EALDH1A1RXFP1CXCL8 | |
| SCHEMBL194831 | 0.69 | CXCL8 (0.65) | CXCL8NR1H4TTRAKR1B10UGT1A9 | |
| SCHEMBL29933245 | 0.69 | CXCL8 (0.65) | CXCL8NR1H4TTRAKR1B10UGT1A9 | |
| SCHEMBL5266212 | 0.69 | DPP4 (0.44) | NR4A2KDM4EALDH1A1ADRA1ADPP4 | |
| SCHEMBL34471968 | 0.69 | ALPL (0.42) | KDM4EALDH1A1HSD17B10KMT2AMAPT | |
| SCHEMBL8396823 | 0.69 | RXFP1 (0.49) | NR4A2KDM4EALDH1A1RXFP1CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105503877-A | Imidazopyridazine compound and application thereof | HUTCHISON MEDIPHARMA LTD | 2016-04-20 | — | — | CN | disclosed |