Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29574354 | 0.79 | KDM4E (0.65) | ALDH1A1KMT2ASMN1; SMN2RAB9ATSHR | |
| SCHEMBL6206542 | 0.79 | KDM4E (0.65) | ALDH1A1KMT2ASMN1; SMN2RAB9ATSHR | |
| SCHEMBL28056343 | 0.77 | NR4A2 (0.45) | ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL25307207 | 0.77 | HTT (0.46) | ALDH1A1KMT2AKDM5BSMN1; SMN2NPC1 | |
| SCHEMBL6545903 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KMT2ASMN1; SMN2NPC1TP53 | |
| SCHEMBL34471968 | 0.75 | ALPL (0.42) | ALDH1A1KMT2AALPLSMN1; SMN2NPC1 | |
| SCHEMBL8946514 | 0.73 | KMT2A (0.54) | ALDH1A1KMT2AHPGDKDM4EDHODH | |
| SCHEMBL5266212 | 0.73 | DPP4 (0.44) | ALDH1A1SMN1; SMN2NPC1TP53HPGD | |
| SCHEMBL8946636 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KMT2AALPLSMN1; SMN2NPC1 | |
| SCHEMBL1623759 | 0.71 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AKDM5BSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106715432-B | New Imidazopyridazines and application thereof | 和记黄埔医药（上海）有限公司 | 2019-03-26 | — | — | CN | disclosed |
| CN-106715432-A | Novel imidazopyridazine compounds and their use | 和记黄埔医药（上海）有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-105503877-A | Imidazopyridazine compound and application thereof | HUTCHISON MEDIPHARMA LTD | 2016-04-20 | — | — | CN | disclosed |